Exosomes are cell-derived extracellular vesicles (EVs) with the same lipid bilayer as the cell membrane, they released from cells into the extracellular space and contains various growth factors, cytokines, mRNA and miRNA. They are excellent regulator for intercellular communication.

There are multiple clinical researches and applications of exosomes in the treatments of tumors, neurons and rare diseases, including disease diagnosis, drug delivery, cell-free therapy.*

*Reference: Chembiochem. 2019 Feb 15; 20(4): 451-461; https://taccplus.com/technews0314/

Growth factors, Cytokines derived from Stem Cells and their mechanisms.

Five main functions of exosomes for therapeutic purposes and health care:

• Anti-Inflammatory
• Immunomodulatory
• Repair and regeneration
• Anti-Aging
• Cell activation

References:

1. Stem Cells Transl Med. 2020 Apr; 9(4):499-517
2. Sci Adv. 2022 Jan 14;8(2):eabj9617
3. Sci Rep. 2020 Sep 3;10(1):14521
4. Bone Res. 2020 Jun 19;8:25
5. J Cosmet Dermatol. 2022 Feb;21(2):844-849
6. Derm Venereol 2020; 100: adv0031
7. https://clinicaltrials.gov

The potential applications of exosomes including treatment of dupilumab- related facial redness in patients with atopic dermatitis, hair regeneration treatment, improve skin texture, improve acne scars after laser treatment, wound healing, improve dry eye syndrome and etc.

References:

1. J Cosmet Dermatol. 2022 Feb;21(2):844-849.
2. Eplasty. 2015 Mar 26
3. Chernoff G. J Surg 6: 1388.
4. Derm Venereol 2020; 100: adv0031
5. Sci Adv. 2022 Jan 14;8(2)

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