What is endometrium receptivity?
An endometrium is receptive when it is ready for embryo implantation. This period of receptivity is called the window of implantation (WOI).
Studies showed that wrong timing of endometrial receptivity is one of the leading causes of recurrent implantation failure (RIF). The results also indicated that 3 in every 10 patients have a displaced WOI (Timeva et al., 2014; Patel et al., 2019).
This is the reason why identifying the optimal day(s) for embryo transfer is essential for implantation.
Examples of miRNA biomarkers for endometrium receptivity
MicroRNAs are the upstream regulators of mRNA that can control the pathways related to endometrial receptivity.
Who could take this test?
- Any women that plans to undergo IVF treatment process.
- Recurrent implantation failures with good quality embryos.
The advantages of MIRA
What is MIRA™?
MIRA™ is a preimplantation testing solution used during the in vitro fertilization process (IVF) to enhance treatment success- find the window of implantation (WOI) for better timing of embryo transfer.
What IVF treatment cycles can be performed with MIRA™?
Natural cycle or hormone replacement therapy (progesterone) cycle.
What biomarker used in MIRA™ to analyse the endometrial status?
MicroRNA which is more stable the mRNA-based method.
Does the biopsy need to be retaken under different treatment cycles?
Yes, if the treatment type or dose is changed, then the biopsy will need to be retaken and MIRA™ needs to be redone. Different treatment cycles or changes in dosage under the same treatment cycle may affect the hormone levels and alter the best timing for embryo implantation, which is why we recommend that MIRA™ should be redone if treatment conditions are altered.