Skip links

MIRA– MicroRNA-based Endometrial Receptivity Analysis

MIRA– MicroRNA-based Endometrial Receptivity Analysis

Description

Overview
Documentation

MIRA is a MicroRNA (miRNA) -based analysis that can assess a combination of miRNA biomarkers in order to determine the status of a female’s endometrium receptivity. This test will identify the best personalized timing for implantation to increase the chances of in vitro fertilization (IVF) treatment success.

Request Information

Overview

What is endometrium receptivity?

An endometrium is receptive when it is ready for embryo implantation. This period of receptivity is called the window of implantation (WOI).

Studies showed that wrong timing of endometrial receptivity is one of the leading causes of recurrent implantation failure (RIF). The results also indicated that 3 in every 10 patients have a displaced WOI (Timeva et al., 2014; Patel et al., 2019).

This is the reason why identifying the optimal day(s) for embryo transfer is essential for implantation.

Examples of miRNA biomarkers for endometrium receptivity

MicroRNAs are the upstream regulators of mRNA that can control the pathways related to endometrial receptivity.

Who could take this test?

  • Any women that plans to undergo IVF treatment process.
  • Recurrent implantation failures with good quality embryos.

The advantages of MIRA

Comparison between MIRA and other endometrial receptivity analysis

What is MIRA?

MIRA is a preimplantation testing solution used during the in vitro fertilization process (IVF) to enhance treatment success- find the window of implantation (WOI) for better timing of embryo transfer.

What IVF treatment cycles can be performed with MIRA?

Natural cycle or hormone replacement therapy (progesterone) cycle.

What biomarker used in MIRA to analyse the endometrial status?

MicroRNA which is more stable the mRNA-based method.

What is the advantage of this test compare to other similar test?

The treatment cycle and sample collection procedure of this test is really similar to other test. However, it is less sample required, which may be less harmful to some thin endometrium patients. Also, using miRNA as biomarker is more stable, so this test can issue the report for each biopsy and without a second biopsy.

How long is the MIRA (MicroRNA receptivity analysis) test valid for?

In our internal data, so far we had tracked some cases that the validity of the test can last for 2 years. But this should be based on the hormone level is at a stable status and the medical treatment is the same. For women who are at advanced maternal age, we suggest it is better to redo the test after 6 months.

Does the biopsy need to be retaken under different treatment cycles?

Yes, if the treatment type or dose is changed, then the biopsy will need to be retaken and MIRA™ needs to be redone. Different treatment cycles or changes in dosage under the same treatment cycle may affect the hormone levels and alter the best timing for embryo implantation, which is why we recommend that MIRA™ should be redone if treatment conditions are altered.

Does this test guarantee the pregnancy rate?

Since pregnancy is very complicated, this test does not guarantee the pregnancy rate. But finding the right timing for implantation is essential, this test indeed can improve the implantation rate and lower the chances of RIF.

Find out more about MIRA

Testing Information

After getting pregnant successfully, pregnant mothers are suggested to do prenatal testing to assure the health of the unborn baby.
American College of Obstetricians and Gynecologists (ACOG) stated that prenatal genetic testing is recommended, especially in IVF-ICSI pregnancies to make sure the unborn baby is free from diseases.

To provide a comprehensive service for pregnant mothers while considering the limitations in every genetic testing, GGA provides high resolution SNP microarray as follow-up diagnostic test for you!

Now GGA would like to extend favors to the pregnant mother who chooses MIRA, you will get a discount on SNP microarray analysis, it is applicable for Prenatal & Newborn & Childhood genetic test.

SNP microarray analysis is recommended for pregnant women who:

  • desires definitive and comprehensive information about fetus.
  • have a family history of congenital anomalies or a previous pregnancy with a fetus with chromosomal abnormalities.
  • have abnormal prenatal findings from ultrasound scans, karyotype, and other screening tests (e.g. NIPT, First/Second-trimester maternal serum Down Syndrome screening).
  • Non-invasive Prenatal Test (NIPT) showing no-call or inconclusive results due to low fetal fraction.
  • carries multiple gestations.
  • achieved pregnancy by Preimplantation Genetic Testing for Aneuploidy (PGT-A).

Kindly contact us for discount details.

For more information about SNP microarray, please visit: https://www.ggasia.com.my/services/snp-microarray-for-amniocentesis/

Documentation

Brochure

Download PDF

Published paper

Download PDF

International clinical collaboration welcomed! Please contact us

Contact Us